Avendo gli anticoagulanti diretti (DOAC) una farmacocinetica e farmacodinamica prevedibile e riproducibile, un rapporto lineare tra dose, concentrazione plasmatica ed effetto anticoagulante, appare evidente come una dose congrua sia di fondamentale importanza per una corretta prevenzione dello stroke nei pazienti portatori di fibrillazione atriale.
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